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Tuesday, April 23, 2013
Monday, April 22, 2013
CA-NEWS Summary
Canada thwarts 'al Qaeda-supported' passenger train plot
TORONTO (Reuters) - Canadian police said on Monday they had arrested and charged two men with plotting to derail a Toronto-area passenger train in an operation they say was backed by al Qaeda elements in Iran. "Had this plot been carried out, it would have resulted in innocent people being killed or seriously injured," Royal Canadian Mounted Police official James Malizia told reporters.
Suspect charged in hospital with Boston Marathon bombing
BOSTON (Reuters) - Prosecutors formally charged Dzhokhar Tsarnaev with the bombings at the Boston Marathon in a hearing held on Monday in his hospital room, accusing him of crimes that carry the possibility of the death penalty. The 19-year-old ethnic Chechen can be seen in video taken by security cameras placing a backpack near the finish line of the world-renowned race last Monday, the criminal complaint said, alleging he acted in concert with his older brother, who was killed during a shootout with police early Friday.
Assad urges Lebanon to help fight his foes: Lebanese delegates
BEIRUT (Reuters) - Syrian President Bashar al-Assad believes neighboring Lebanon cannot shield itself from the civil war in his country and that both states should fight his opponents, three members of a Lebanese delegation who visited Assad said on Monday. Lebanon, which suffered its own civil war from 1975 to 1990 and endured a military presence by its historically dominant neighbor for 29 years until 2005, has maintained a policy of "dissociation" from Syria's two-year-old conflict.
Insight: China consolidates sea claims as Asian diplomacy struggles
MASINLOC, Philippines (Reuters) - For decades, fishermen along the northwestern Philippine coast treated the teeming fishing grounds of the Scarborough Shoal as their backyard, less than a day's boat ride away. Now, they see it as a foreign country.
Heavy fighting in northeast Nigeria, death toll unclear
ABUJA (Reuters) - Nigerian authorities said on Monday there had been heavy fighting between security forces and Islamist militants in a remote part of the northeast, but there was no confirmation of reports from a local official that 185 people had been killed. Fighting erupted on Thursday in Baga, a fishing town in Borno state on the shores of Lake Chad, by the Chadian border -- an area officials say is a stronghold for Islamist fighters and a smuggling point for weapons from across the Sahara.
Palestinian prisoner in deal with Israel to end fast
RAMALLAH, West Bank (Reuters) - A Palestinian prisoner held by Israel has agreed to end an on-off hunger strike on Monday which lasted for more than eight months in exchange for an early release, Palestinian officials told Reuters. The fast by Samer al-Issawi, 32, from a suburb of Jerusalem, had stoked weeks of street protests and concerns by Israel that his death might lead to mass unrest.
Iran is biggest threat to nuclear pact's credibility: U.S.
GENEVA (Reuters) - Iran's nuclear program poses the greatest threat to the credibility of the global pact aimed at halting the spread of atomic weapons, a senior U.S. arms control official said on Monday. The Islamic Republic has a "long history" of deceiving the International Atomic Energy Agency (IAEA) and its nuclear enrichment program far exceeds that needed for civilian use, said Thomas Countryman, Assistant Secretary for International Security and Nonproliferation.
Japan nationalists close to islands disputed by China
EAST CHINA SEA (Reuters) - A flotilla of boats carrying more than 80 Japanese nationalists arrived on Tuesday in waters near disputed islands at the centre of tensions between China and Japan, risking further straining Tokyo's fraught relations with its Asian neighbors. The boats were shadowed by at least 10 Japanese Coast Guard vessels, while three Chinese government surveillance ships moved near the islands, according to the JCG.
Irate Italian president to begin talks on new coalition
ROME (Reuters) - Italy's president launches urgent talks on Tuesday that could see a prime minister designated after two months of post-electoral stalemate that has weighed on a stagnant economy and alarmed Rome's partners in the euro. After directing an emotional blast of impatience on Monday at the very parliament which handed him an unprecedented - and heartily unwanted - second term as head of state at the weekend, 87-year-old Giorgio Napolitano has announced a "rapid round of consultations" with political leaders, starting early Tuesday.
Colombia's Santos changes mind on two-year re-election bid
BOGOTA (Reuters) - Colombian President Juan Manuel Santos on Monday said he is no longer considering running for a shorter term of two years in 2014 and told lawmakers it was too early to consider an extension of presidential terms to six years. Santos on Friday signaled he may seek re-election, but only if he can stay in office for two more years, half the usual term. He also said that from 2016 onwards, the presidential term should be extended to six years and that a president's right to stand for re-election should be scrapped.
Source: http://news.yahoo.com/ca-news-summary-003014290.html
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For development in Brazil, two crops are better than one
Apr. 22, 2013 ? It's not just about agriculture. Growing two crops a year in the same field improves schools, helps advance public sanitation, raises median income, and creates jobs.
New research finds that double cropping -- planting two crops in a field in the same year -- is associated with positive signs of economic development for rural Brazilians.
The research focused the state of Mato Grosso, the epicenter of an agricultural revolution that has made Brazil one of the world's top producers of soybeans, corn, cotton, and other staple crops. That Brazil has become an agricultural powerhouse over the last decade or so is clear. What has been less clear is who is reaping the economic rewards of that agricultural intensification -- average Brazilians or wealthy landowners and outside investors.
Leah VanWey, associate professor of sociology at Brown University and the study's lead author, says her results suggest at least one type of agricultural intensification -- double cropping -- is associated with development that improves well-being for average rural Brazilians.
Looking at agricultural and economic data from the last decade, VanWey found that in munic?pios (counties) where double cropping is common, GDP and median per capita income were both substantially higher. Double cropping was also associated with higher quality schools and better public sanitation. "We looked at two indicators of private goods and two indicators of public goods," VanWey said. "Overall, we find this really nice pattern of impacts on development associated with double cropping. These benefits seem to be widespread through the population."
Meanwhile, intensification to single-crop fields from pasture with low stocking rates was not associated with development gains, the research found. VanWey says that is probably because double cropping is more labor intensive, which creates jobs, and more lucrative, which creates more tax revenue that can be invested in public goods. That was evidenced by a case study of two counties within Mato Grosso that was part of this new research.
"The community with the most double cropping also has a soy processing plant that employs thousands of workers as well as complementary poultry and swine raising and processing," VanWey said. "In the long run there isn't much money in just growing things and selling them, but processing allows the local area and workers to retain more of the per-unit cost of the final product."
The findings are published in an issue of Philosophical Transactions of the Royal Society B focused on agricultural development in Brazil.
Mato Grosso has drawn much attention from scholars in recent years. It is not only the heart of Brazil's agricultural production but also sits on the border of the nation's cerrada (savanna) biome and the Amazon rainforest biome. Some evidence over the last decade suggests that even as agricultural production in the state has increased, deforestation in the Amazon region has slowed. For that reason, the state is seen by many as a model for agricultural development that minimizes harm to the environment.
To understand how land use is associated with economic development, VanWey teamed with John Mustard, professor of geological sciences at Brown, and Stephanie Spera, Mustard's graduate student. Spera and Mustard used imaging from NASA's Terra satellite to track land use changes in Mato Grosso from 2000 to 2011. They captured satellite images of the region every 16 days for a year. They looked for peaks in the greenness of the fields followed by a rapid loss of greenness, indicating the ripening and subsequent harvesting of a crop. Two peaks in greenness in the same year is an indicator that a field is double-cropped. Spera and Mustard recorded images from 2000 to 2001, and again from 2010 to 2011, to see how usage had changed over the decade. They found substantial increases in both single- and double-cropped fields.
VanWey then matched those data to local economic data, with the help of Brown undergraduates Rebecca de Sa and Dan Mahr.
The research showed that intensification to single-crop fields from pasture had no effect on economic variables. Double cropping, however, was associated with strong gains. For example, where double cropping was common, median income was substantially higher. According to VanWey's calculations, median income for citizens of Mato Grosso would be decreased from 346 Brazilian reals per month (about $190) to 144 reals without the effects of double cropping. On the other hand, if all areas double cropped, monthly income would increase to 459 reals.
"[Double cropping] increases median incomes in an entire county, not just among people working in agriculture," VanWey said. "So I'm arguing that it's going to have these effects on the entire economy by providing employment that's related to the agriculture."
The positive association with public goods such as schools was strong as well. For that analysis, VanWey looked at a 10-point quality assessment scale used by the Brazilian government. She calculated that if all areas of Mato Grosso double cropped, scores on the assessment for public schools would increase from an average of 4.2 to 5.4.
The increases in measures of both personal wealth and public goods suggest widespread economic development associated with double cropping, VanWey concludes. However she's not yet ready to advocate for public policy steps like blanket subsidies for double cropping. More research needs to be done, she says, to find out why double cropping thrives in some places but not others.
She and her colleagues are working on those questions now.
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The above story is reprinted from materials provided by Brown University.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Leah K. VanWey, Stephanie Spera, Rebecca de Sa, Dan Mahr, and John F. Mustard. Socioeconomic development and agricultural intensification in Mato Grosso. Phil. Trans. R. Soc. B., 2013 DOI: 10.1098/rstb.2012.0168
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
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Google Now, Donna, Sherpa, And The Rise Of The Smart Personal Assistant App
Mobile personal assistant apps are all the rage these days. First there was Google Now for Android, but over the last several weeks we’ve seen a whole bunch of new apps pop up — apps like Donna, Osito, and Sherpa — all of which seek to make our lives easier by simplifying how we organize our meetings, travel, and other personal information. With that in mind, I sat down with my colleague Drew Olanoff to discuss why this is such a hot space and whether these apps deliver on their promise. On that latter question, we still think these apps have a long way to go. As Drew says, all the technology is there — and yet, no one has really pulled it all together in a way that makes these apps truly smart. There’s also the issue of finding an app that fits everyone’s lifestyle. As he points out, his personal workflow is different from mine. Finding a way to make a personal assistant that suits everyone’s needs is a difficult process. As for me? I like what I’ve seen so far from apps like Donna or Osito, but I don’t want an app that I have to enter information into to make things work. I want something that will scour my email and calendars, figure out where and when things are happening, and then from that information plan my calendar for me. No one quite comes close right now. Check out the video above for our discussion on the topic, and let us know what you think in the comments.Source: http://feedproxy.google.com/~r/Techcrunch/~3/_T5MjuD1s6s/
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Thursday, April 11, 2013
SAfrica: H7N1 bird flu found in ostrich farm
JOHANNESBURG (AP) ? South African officials say they have detected bird flu on an ostrich farm but that it is unrelated to the strain that has killed eight people in China.
Still, the discovery is another blow for an industry that has lost 40 percent of its 50,000 farmers since the European Union imposed a ban on imports of South African ostrich meat after a 2011 outbreak.
Then, officials killed 50,000 birds infected with the H5N2 strain.
Western Cape agriculture chief Gerrit van Rensburg said Tuesday that officials detected the H7N1 strain near the southwestern town of Oudtshoorn. He said they had quarantined farms in a three-kilometer (two-mile) radius for an intensive epidemiological investigation.
Van Rensburg says the impact of the new outbreak would be clearer once test results come in.
Source: http://news.yahoo.com/safrica-h7n1-bird-flu-found-ostrich-farm-200943553.html
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Wednesday, April 10, 2013
Another Big Ol? Booty Coming Between Kanye & Kim Kardashian?
Another Big Ol’ Booty Coming Between Kanye & Kim Kardashian?
Another Big Ol’ Booty Coming Between Kanye & Kim Kardashian? Stupid Celebrities Gossip Stupid Celebrities Gossip News
Source: http://stupidcelebrities.net/2013/04/another-big-ol-booty-coming-between-kanye-kim-kardashian/
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DragonWave cuts 33 pct jobs, amends deal with Nokia Siemens
(Reuters) - Telecom network equipment maker DragonWave Inc
Cash-strapped DragonWave, which has been trying to reduce costs since it acquired Nokia Siemens's microwave technology business last June, said last month that it would cut costs further but did not specify what the measures were.
The company cut 116 jobs in Ottawa and Israel in 2012.
According to the renewed deal, Nokia Siemens will make an immediate cash payment of $13.8 million to DragonWave, clearing the contingent receivable on the Ottawa-based company's balance sheet.
DragonWave said the companies have ended the Italian services agreement, under which Nokia Siemens provided research and development and certain other services to DragonWave since June 2012.
DragonWave expects operating costs to fall by about 3 million euros per quarter. Nokia Siemens will take on additional commitments and costs.
DragonWave, which uses microwave technology to move data between cellular towers and telecom networks, warned in March that fourth-quarter revenue would miss its forecast due to lower sales in the unit.
The unit contributed $25.6 million, or about 67 percent, to DragonWave's revenue in the third quarter.
DragonWave said on Wednesday it expects to pay a termination fee of about 7 million euros over the balance of fiscal year 2014.
The company said it would continue to be the preferred supplier of packet microwave and related products to Nokia Siemens, and both companies would jointly coordinate technology development activities.
Shares of DragonWave closed at C$1.60 on the Toronto Stock Exchange on Tuesday. The stock has lost more than a third of its value since it lowered its revenue estimate.
($1 = 0.7658 euros)
(Reporting by Bhaswati Mukhopadhyay in Bangalore; Editing by Roshni Menon)
Source: http://news.yahoo.com/dragonwave-cuts-33-pct-jobs-amends-deal-nokia-104959967--sector.html
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Monday, April 8, 2013
Engineered T cells kill tumors but spare normal tissue in an animal model
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_vuAwhojgGTgpv6TWSxIgHcaQSmYP7NFp3cly5Ik6PlxAfffPZ_LVVeaC3FXms2o1cCm4FS4iU6rJfAcNchgLjkLHDinZtCdWQFIgbAc_A=s0-d){kind=small}
Public release date: 7-Apr-2013[ | E-mail |
Share ] Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
PHILADELPHIA The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer. Identifying which antigens a patient's tumor cells express is the cornerstone of designing cancer therapy for that individual. But some of these tumor antigens are also expressed on normal cells, inching personalized therapy back to the original problem.
T cells made to express a protein called CAR, for chimeric antigen receptor, are engineered by grafting a portion of a tumor-specific antibody onto an immune cell, allowing them to recognize antigens on the cell surface. Early first-generation CARs had one signaling domain for T-cell activation. Second-generation CARs are more commonly used and have two signaling domains within the immune cell, one for T-cell activation and another for T- cell costimulation to boost the T cell's function.
Importantly, CARs allow patients' T cells to recognize tumor antigens and kill certain tumor cells. A large number of tumor-specific, cancer-fighting CAR T cells can be generated in a specialized lab using patients' own T cells, which are then infused back into them for therapy. Despite promising clinical results, it is now recognized that some CAR-based therapies may involve toxicity against normal tissues that express low amounts of the targeted tumor-associated antigen.
To address this issue, Daniel J. Powell Jr., PhD, research assistant professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, and director of the Cellular Therapy Tissue Facility, developed an innovative dual CAR approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.
Powell likens this dual CAR approach to having two different gas pedals, one for starting the immune system and a second for revving it up. Dual CAR T cells are more selective for tumor cells since their full activity requires interaction with both antigens, which are only co-expressed on tumor cells, not normal tissue.
Dual CAR T cells showed weak cytokine production against target cells expressing only one tumor-associated antigen in lab assays, similar to first-generation CAR T cells bearing the CD3 activation domain only, but demonstrated enhanced cytokine production upon encountering natural or engineered tumor cells expressing both antigens, equivalent to second-generation CAR T cells with dual, but unseparated signaling.
In a mouse model of human ovarian cancer, T cells with the dual-signaling CARs persisted at high numbers in the blood, accumulated in tumors, and showed potent anti-cancer activity against human tumors. Dual CAR T cells were equivalent to second-generation CAR T cells in activity against tumors bearing two antigens. However, the dual-signaling CAR T cells did not react vigorously with normal tissue expressing one antigen while second- generation CAR T cells did.
"This new dual-specificity CAR approach can enhance the therapeutic efficacy of CAR T cells against cancer while minimizing reactivity against normal tissues," says Powell.
Their findings have been published in the inaugural issue of Cancer Immunology Research, the newest journal from the American Association for Cancer Research.
###
This work was supported by grants from the W.W. Smith Charitable Trust, the Sandy Rollman Ovarian Cancer Foundation, the Ovarian Cancer Research Fund (PPD-Penn-01.12), the National Cancer Institute (RO1-CA168900) and the Joint Fox Chase Cancer Center and University of Pennsylvania Ovarian Cancer SPORE (P50 CA083638).
Co-authors include Evripidis Lanitis, Mathilde Poussin, Alex W. Klattenhoff, Degang Song, and Carl H. June, all from Penn.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 7-Apr-2013[ | E-mail |
Share ] Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-459-0544
University of Pennsylvania School of Medicine
PHILADELPHIA The need to distinguish between normal cells and tumor cells is a feature that has been long sought for most types of cancer drugs. Tumor antigens, unique proteins on the surface of a tumor, are potential targets for a normal immune response against cancer. Identifying which antigens a patient's tumor cells express is the cornerstone of designing cancer therapy for that individual. But some of these tumor antigens are also expressed on normal cells, inching personalized therapy back to the original problem.
T cells made to express a protein called CAR, for chimeric antigen receptor, are engineered by grafting a portion of a tumor-specific antibody onto an immune cell, allowing them to recognize antigens on the cell surface. Early first-generation CARs had one signaling domain for T-cell activation. Second-generation CARs are more commonly used and have two signaling domains within the immune cell, one for T-cell activation and another for T- cell costimulation to boost the T cell's function.
Importantly, CARs allow patients' T cells to recognize tumor antigens and kill certain tumor cells. A large number of tumor-specific, cancer-fighting CAR T cells can be generated in a specialized lab using patients' own T cells, which are then infused back into them for therapy. Despite promising clinical results, it is now recognized that some CAR-based therapies may involve toxicity against normal tissues that express low amounts of the targeted tumor-associated antigen.
To address this issue, Daniel J. Powell Jr., PhD, research assistant professor of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, and director of the Cellular Therapy Tissue Facility, developed an innovative dual CAR approach in which the activation signal for T cells is physically dissociated from a second costimulatory signal for immune cells. The two CARs carry different antigen specificity -- mesothelin and a-folate receptor. Mesothelin is primarily associated with mesothelioma and ovarian cancer, and a-folate receptor with ovarian cancer.
Powell likens this dual CAR approach to having two different gas pedals, one for starting the immune system and a second for revving it up. Dual CAR T cells are more selective for tumor cells since their full activity requires interaction with both antigens, which are only co-expressed on tumor cells, not normal tissue.
Dual CAR T cells showed weak cytokine production against target cells expressing only one tumor-associated antigen in lab assays, similar to first-generation CAR T cells bearing the CD3 activation domain only, but demonstrated enhanced cytokine production upon encountering natural or engineered tumor cells expressing both antigens, equivalent to second-generation CAR T cells with dual, but unseparated signaling.
In a mouse model of human ovarian cancer, T cells with the dual-signaling CARs persisted at high numbers in the blood, accumulated in tumors, and showed potent anti-cancer activity against human tumors. Dual CAR T cells were equivalent to second-generation CAR T cells in activity against tumors bearing two antigens. However, the dual-signaling CAR T cells did not react vigorously with normal tissue expressing one antigen while second- generation CAR T cells did.
"This new dual-specificity CAR approach can enhance the therapeutic efficacy of CAR T cells against cancer while minimizing reactivity against normal tissues," says Powell.
Their findings have been published in the inaugural issue of Cancer Immunology Research, the newest journal from the American Association for Cancer Research.
###
This work was supported by grants from the W.W. Smith Charitable Trust, the Sandy Rollman Ovarian Cancer Foundation, the Ovarian Cancer Research Fund (PPD-Penn-01.12), the National Cancer Institute (RO1-CA168900) and the Joint Fox Chase Cancer Center and University of Pennsylvania Ovarian Cancer SPORE (P50 CA083638).
Co-authors include Evripidis Lanitis, Mathilde Poussin, Alex W. Klattenhoff, Degang Song, and Carl H. June, all from Penn.
Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.
The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.
The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/uops-etc040213.php
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SARAH HARDING DEFIANT - Daily Star
ABOVE: Sarah Harding is facing a criminal charge
Sarah was very upset when she was arrested and charged. The offences are pretty serious.
8th April 2013
By Meg Jorsh
SARAH HARDING stuck two fingers up at the police after her mobile phone driving arrest.
The ex-Girls Aloud babe, 31, tweeted afterwards: ?If I?d observed all the rules I?d never have got anywhere.?
She allegedly tried to outrun a police cyclist who spotted her making a call behind the wheel of her 4x4.
She was flagged down on Charing Cross Road, central London, at 6pm on Thursday. Sarah was then taken to Holborn Police Station after a roadside conversation with officers.
A source said: ?Sarah was very upset when she was arrested and charged. The offences are pretty serious.?
But by Saturday night, the singer was back in her studio at home in Chalfont St Peter, Bucks.
As she worked on material for her new solo career, worried Sarah told her 96,000 Twitter followers: ?Hope u get 2 hear it. If the cover track I?m about to record in my studio tonight didnt relate to most of humanity I probably wouldn?t bother.?
She has been bailed to appear on two charges at London?s Highbury Magistrates? Court on April 16.
She faces a maximum ?1,000 fine and losing her licence for talking on her mobile and a further ?5,000 fine for failing to stop for police.
A Metropolitan Police spokesman said: ?The charges are failing to stop for police and driving whilst using a mobile phone.?
The singer experienced difficult times after her break-up from DJ fianc? Tom Crane, 32, in September 2011.
She checked into rehab in South Africa for addiction to sleeping pills and alcohol shortly afterwards and had a violent hotel bust-up with boyfriend Theo De Vries, 36, whom she met at the clinic.
But last week, she claimed to be ?200% better? since settling with new lover, the DJ MRK1.
The arrest comes after Girls Aloud announced they have split for good after a 10-year reunion tour earlier this year.
Source: http://www.dailystar.co.uk/news/view/307935/SARAH-HARDING-DEFIANT/
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Sunday, April 7, 2013
Flies model a potential sweet treatment for Parkinson's disease
Apr. 6, 2013 ? Researchers from Tel Aviv University describe experiments that could lead to a new approach for treating Parkinson's disease (PD) using a common sweetener, mannitol.
This research is presented today at the Genetics Society of America's 54th Annual Drosophila Research Conference in Washington D.C., April 3-7, 2013.
Mannitol is a sugar alcohol familiar as a component of sugar-free gum and candies. Originally isolated from flowering ash, mannitol is believed to have been the "manna" that rained down from the heavens in biblical times. Fungi, bacteria, algae, and plants make mannitol, but the human body can't. For most commercial uses it is extracted from seaweed although chemists can synthesize it. And it can be used for more than just a sweetener.
The Food and Drug Administration approved mannitol as an intravenous diuretic to flush out excess fluid. It also enables drugs to cross the blood-brain barrier (BBB), the tightly linked cells that form the walls of capillaries in the brain. The tight junctions holding together the cells of these tiniest blood vessels come slightly apart five minutes after an infusion of mannitol into the carotid artery, and they stay open for about 30 minutes.
Mannitol has another, less-explored talent: preventing a sticky protein called ?-synuclein from gumming up the substantia nigra part of the brains of people with PD and Lewy body dementia (LBD), which has similar symptoms to PD. In the disease state, the proteins first misfold, then form sheets that aggregate and then extend, forming gummy fibrils.
Certain biochemicals, called molecular chaperones, normally stabilize proteins and help them fold into their native three-dimensional forms, which are essential to their functions. Mannitol is a chemical chaperone. So like a delivery person who both opens the door and brings in the pizza, mannitol may be used to treat Parkinson's disease by getting into the brain and then restoring normal folding to ?-synuclein.
Daniel Segal, PhD, and colleagues at Tel Aviv University investigated the effects of mannitol on the brain by feeding it to fruit flies with a form of PD that has highly aggregated ?-synuclein.
The researchers used a "locomotion climbing assay" to study fly movement. Normal flies scamper right up the wall of a test tube, but flies whose brains are encumbered with ?-synuclein aggregates stay at the bottom, presumably because they can't move normally. The percentage of flies that climb one centimeter in 18 seconds assesses the effect of mannitol.
An experimental run tested flies daily for 27 days. After that time, 72% of normal flies climbed up, in comparison to 38% of the PD flies. Their lack of ascension up the sides of the test tube indicated "severe motor dysfunction."
In contrast, were flies bred to harbor the human mutant ?-synuclein gene, who as larvae feasted on mannitol that sweetened the medium at the bottoms of their vials. These flies fared much better -- 70% of them could climb after 27 days. And slices of their brains revealed a 70% decrease in accumulated misfolded protein compared to the brains of mutant flies raised on the regular medium lacking mannitol.
It's a long way from helping climbing-impaired flies to a new treatment for people, but the research suggests a possible novel therapeutic direction. Dr. Segal, however, cautioned that people with PD or similar movement disorders should not chew a ton of mannitol-sweetened gum or sweets; that will not help their current condition. The next step for researchers is to demonstrate a rescue effect in mice, similar to improved climbing by flies, in which a rolling drum ("rotarod") activity assesses mobility.
"Until and if mannitol is proven to be efficient for PD on its own, the more conservative and possibly more immediate use can be the conventional one, using it as a BBB disruptor to facilitate entrance of other approved drugs that have problems passing through the BBB," Dr. Segal said. A preliminary clinical trial of mannitol on a small number of volunteers might follow if results in mice support those seen in the flies, he added, but that is still many research steps away.
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The above story is reprinted from materials provided by Genetics Society of America, via Newswise.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Tbahh3a8bWY/130407090737.htm
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Saturday, April 6, 2013
Ford injects the pickup truck with next-generation technologies
For decades, the pickup truck has been the redneck-jock of automobiles ? big, strong, dirty and not necessarily all that smart or refined. With the Atlas Concept, Ford envisions a future where the pickup truck adds a dose of technology and refinement. Consider the Atlas Concept that infuriating jock that managed to get straight As while playing a sport every season.
Large pickup trucks have traditionally served as utilitarian work oxen, hauling provisions to remote worksites, towing cargo trailers, and performing other jobs that would cause lesser vehicles to resign on the spot. They're defined by those types of roles, using muscular gas and diesel engines, off-road-ready drive configurations, and big cargo beds to get things done.
Ford intends for future pickups to keep those qualities, which have long endeared them to the likes of cowboys and construction crews, but with a bit more thoughtfulness. Ford refers to the concept as "working and playing smarter, not harder."
The Atlas begins "working smarter" before the driver even gets behind the wheel. A Cargo Cradle rises off the tailgate and provides extra support for long cargo while freeing up bed space. Cargo Ramps stored underneath the bed make it easy to wheel tractors, quads and other equipment up into the bed. The Dynamic Hitch Assist precisely lines up the truck hitch and trailer coupling, delivering visual cues on the Atlas' infotainment display. An integrated roof carrier and cargo bed tie-down points add even more hauling versatility.
Once everything is loaded, the Atlas eases the strain of driving a heavy, cumbersome work truck. The Trailer Backup Assist makes it easier to back a trailer, and the 360-degree bird's eye-view camera delivers a full view of the truck, useful in maneuvering through and parking in tight spaces. The concept also has more traditional driver-assist systems like Blind Spot Information System, Lane Departure Warning and adaptive cruise control.
Once at work, the Atlas provides several helpful advantages. LED spotlights on the side mirrors illuminate the job site for work that doesn't end when the sun goes down, and LEDs on the cargo bed ensure that workers can easily find their tools. The 110-volt electrical outlets in the bed and cabin serve to provide power and charging.
Fuel economy is usually a secondary consideration to truck users that need something that is large and capable, but Ford reasons that there's no reason not to get as much economy as possible out of its truck. The Atlas is powered by a next-generation EcoBoost engine with truck-optimized Auto Start-Stop and a fuel-saving transmission. The start-stop feature shuts down the engine when stopped in traffic but keeps the engine running when the truck is towing a load. A series of efficiency-optimizing technologies, including active grille shutters, active wheel shutters, drop-down front air dam, and power running boards, improve aerodynamics to get even more mileage.
Ford updates its truck interior with "thin, lightweight" leather seating designed to increase legroom; oversized, glove-friendly controls; ice blue lighting; and an infotainment system with "truck apps," MyFord Touch and SYNC. Multiple USB ports charge smaller, more techy tools of the trade. The Intelligent Access system automatically unlocks doors and tailgate when the owner approaches.
Ford introduced the Atlas Concept at the 2013 North American International Auto Show in January. This week it further highlighted the conceptual truck by showing how some initial ideas were refined into the features actually included on the Detroit concept car.
The distinctive Cargo Cradle, for instance, was created as a means of adding usefulness to the traditional tailgate, which began with the idea of a tailgate-integrated storage box. Similarly, the lighting for the bed was moved from the truck roof to the cargo box walls.
Take a look at the gallery for more angles of the Atlas concept and other features that were dropped or refined from earlier iterations.
Source: Ford
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Friday, April 5, 2013
Postal processing relocating to Richmond, 450 jobs "reassigned"
WVEC.com
Posted on April 5, 2013 at 4:48 PM
Updated today at 5:41 PM
NORFOLK--The U.S. Postal Service will begin to shift processing of local mail from Norfolk to the Richmond area over the summer, increasing delivery times and uprooting families from the region, a union leader said Thursday.
Last week, workers learned from agency officials that the Postal Service would begin shifting the processing of mail to Sandston in June or July. The transition will be completed by the end of 2014.
More than 450 jobs will be lost at the Norfolk Processing and Distribution Center on Church Street, with employees "involuntarily reassigned," according to Michelle Wright, president of the Norfolk local of the American Postal Workers Union.
The move affects 211 clerks, with Wright among them, 150 mail handlers who move mail containers, and 92 maintenance employees, Wright said.
The reassignments could remove many families from the area if they go where the jobs are, according to Wright.
?It?s potentially an uprooting of families. It?s potentially an economic issue where people may have to sell their homes or take their kids out of school,? said Wright.
Many USPS customers are concerned that services will be jeopardized by consolidating the centers.
?I don?t think it?s not so much the processing center as it is the focus on Hampton Roads as a community in the state in general and getting services and funding that we need here. Well, I?ll consider UPS more often,? said Norfolk resident Jane Frazier.
Wright said a letter sent from Norfolk to Virginia Beach would take two days to deliver rather than one because it would have to travel to Richmond and back.
?I think of the Post Office, in my mind, as the agency that serves every person in the United States, it should have a responsibility to the community in which it's in to make sure that those people continue to get the service that they expect,? said Wright.
Source: http://www.wvec.com/my-city/norfolk/450-jobs-reasigned-as-P-201669391.html
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Thursday, April 4, 2013
Microsoft updates SkyDrive for iOS to v3.0, touts support for more devices and revamped user experience
It's been quite a few months since Microsoft touched the SkyDrive application on Apple's mobile platform, but today, after some well-documented delays, the company's finally delivering an update to its iOS offering -- a pretty hefty one, no less. Included in this new version is, most notably, added support for the iPhone 5 and iPad mini, while a refreshed overall user experience, new app icons and enhanced saving options are also in tow with this release. In addition to these tidbits, SkyDrive will now allow iDevice users to easily grab their full-res photos from within the app, as well as determine the size of uploaded and downloaded picture files. Better yet, the long-overdue update just went live in the App Store, so it's about that time for Redmond's cloud surfers to savor what they'd been patiently waiting for.
Filed under: Cellphones, Tablets, Software, Mobile, Microsoft
Source: Inside SkyDrive, App Store
Source: http://www.engadget.com/2013/04/03/microsoft-skydrive-ios-update/
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Wednesday, April 3, 2013
Leno to leave NBC's 'Tonight Show' next spring
This undated promotional image released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," left, and Jimmy Fallon, host of "Late Night with Jimmy Fallon," in Los Angeles. NBC on Wednesday, April 3, 2013 announced its long-rumored switch in late night, replacing incumbent Jay Leno at "The Tonight Show" with Jimmy Fallon and moving the iconic franchise back to New York. Leno will wrap up what will be 22 years of headlining the iconic late-night show in Spring 2014. "Saturday Night Live" producer Lorne Michaels will take over as producer of the new "Tonight Show." (AP Photo/NBC, Andrew Eccles)
This undated promotional image released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," left, and Jimmy Fallon, host of "Late Night with Jimmy Fallon," in Los Angeles. NBC on Wednesday, April 3, 2013 announced its long-rumored switch in late night, replacing incumbent Jay Leno at "The Tonight Show" with Jimmy Fallon and moving the iconic franchise back to New York. Leno will wrap up what will be 22 years of headlining the iconic late-night show in Spring 2014. "Saturday Night Live" producer Lorne Michaels will take over as producer of the new "Tonight Show." (AP Photo/NBC, Andrew Eccles)
FILE - This Jan. 13, 2013 file photo shows Jay Leno, host of "The Tonight Show with Jay Leno," left, and Jimmy Fallon, host of "Late Night with Jimmy Fallon" backstage at the 70th Annual Golden Globe Awards in Beverly Hills, Calif. As Jay Leno lobs potshots at ratings-challenged NBC in his "Tonight Show" monologues, speculation is swirling the network is taking steps to replace the host with Jimmy Fallon next year and move the show from Burbank to New York. NBC confirmed Wednesday, March 20, it's creating a new studio for Fallon in New York, where he hosts "Late Night." But the network did not comment on a report that the digs at its Rockefeller Plaza headquarters may become home to a transplanted, Fallon-hosted "Tonight Show." (Photo by Jordan Strauss/Invision/AP, file)
This Nov. 5, 2012 photo released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," on the set in Burbank, Calif. As Jay Leno lobs potshots at ratings-challenged NBC in his "Tonight Show" monologues, speculation is swirling the network is taking steps to replace the host with Jimmy Fallon next year and move the show from Burbank to New York. NBC confirmed Wednesday, March 20, it's creating a new studio for Fallon in New York, where he hosts "Late Night." But the network did not comment on a report that the digs at its Rockefeller Plaza headquarters may become home to a transplanted, Fallon-hosted "Tonight Show." (AP Photo/NBC, Paul Drinkwater)
This Oct. 24, 2012 photo released by NBC shows Jay Leno, host of "The Tonight Show with Jay Leno," on the set in Burbank, Calif. NBC announced Wednesday, April 3, 2013 that Jimmy Fallon is replacing Jay Leno as the host of "The Tonight Show" in spring 2014. (AP Photo/NBC, Paul Drinkwater)
This Feb. 18, 2013 photo released by NBC shows Jimmy Fallon, host of "Late Night with Jimmy Fallon," on the set in New York. As Jay Leno lobs potshots at ratings-challenged NBC in his "Tonight Show" monologues, speculation is swirling the network is taking steps to replace the host with Jimmy Fallon next year and move the show from Burbank to New York. NBC confirmed Wednesday, March 20, it's creating a new studio for Fallon in New York, where he hosts "Late Night." But the network did not comment on a report that the digs at its Rockefeller Plaza headquarters may become home to a transplanted, Fallon-hosted "Tonight Show." (AP Photo/NBC, Lloyd Bishop)
NEW YORK (AP) ? NBC on Wednesday announced its long-rumored switch in late night, replacing Jay Leno at the "Tonight" show with Jimmy Fallon and moving the iconic franchise back to New York.
Fallon will take over in about a year, the switch coinciding with NBC's coverage of the 2014 Winter Olympics. Veteran "Saturday Night Live" producer Lorne Michaels also will take over as executive producer of "Tonight."
NBC made no announcement on who would replace Fallon at the 12:35 a.m. "Late Night" slot, although Seth Meyers of "Saturday Night Live" is considered a strong candidate.
The change at "Tonight," the longest-running and most popular late-night talk show, had been widely reported but not confirmed by the network until Wednesday. NBC reportedly just wrapped up negotiations with Fallon on a contract extension.
Steve Burke, chief executive officer of NBC Universal, said the network is purposefully making the move when Leno is still at the top of the ratings, just as when Leno replaced Johnny Carson at "Tonight" in 1992.
"Jimmy Fallon is a unique talent, and this is his time," Burke said.
Leno, in a statement, offered his congratulations to Fallon.
"I hope you're as lucky as me and hold on to the job until you're the old guy," he said. "If you need me, I'll be at the garage."
Fallon said, "I'm really excited to host a show that starts today instead of tomorrow."
Emotions were mixed among people waiting outside Leno's Burbank, Calif., studio to attend the taping of Wednesday's "Tonight" show.
"We love you, Jimmy!" said Natalie Renfro, 45, of Salt Lake City. But she gave a shout out to Leno, too: "I'll miss that big chin!"
Ryan Kelly, 39, of Los Angeles, said he's a Leno fan but added that the comedian has "had a good run. ... It's probably time for a fresh face. He's done a good job and I'm sure he'll pop up on TV somewhere else."
As for switching to Fallon, "I'll give it a shot," Kelly said.
Leno couldn't resist a jab at NBC in his monologue Wednesday, even as he as he lauded Fallon as "a hell of a guy" who is going to do a "great job."
"I just have one request for Jimmy: We've all fought, kicked and scratched to get this network up to fifth place. Now we have to keep it there. Jimmy, don't let it slip into sixth!" Leno joked, according to an NBC transcript.
Fallon took a puckish approach in his monologue.
"Welcome! This is 'Late Night with Jimmy Fallon ... for now," he said. "You guys probably heard the news: I'm going to be taking over the 'Tonight Show' next February! But don't worry. Until February, our focus is right here on whatever this show is called."
On his "Late Show" Wednesday on CBS, David Letterman feasted on NBC's announcement.
"Jay Leno now is being replaced, and this is the second time this has happened," he said in his monologue. "I mean, it's crazy. He's being replaced by a younger late night talk show host ? what could possibly go wrong? Honestly. They had pretty good luck with this in the past."
Later, Letterman offered a backhanded salute to Leno that wished him well with his stand-up appearances.
"But good luck to Jay. I know he'll be out on the road, getting it done and taking care of business. And congratulations on a nice long run there at the 'Tonight Show,' if, in fact, you're not coming back," Letterman said, according to a CBS transcript.
He devoted his Top 10 list to "things we'll miss about Jay Leno," including this at No. 4: "Can't remember the name of the bit, but it's the one where Jay is walking."
NBC has been quietly building a new studio for Fallon at its Rockefeller Center headquarters. "Tonight" began in New York in the 1950s, but Carson moved it to California in 1972. Starting next year, Fallon, Letterman, Jon Stewart and Stephen Colbert will tape late-night shows in New York. ABC's Jimmy Kimmel and TBS's Conan O'Brien will be the top California-based shows.
"The 'Tonight' show will bring even more jobs and economic activity to our city, and we couldn't be happier that one of New York's own is bringing the show back to where it started, and where it belongs," said New York Mayor Michael Bloomberg.
New York state recently added a tax credit in its budget that seemed designed specifically to benefit NBC's move east with "Tonight."
While a storied part of television tradition, the network late-night shows find themselves with much more competition now with cable programs like "Adult Swim," smaller talk shows hosted by Chelsea Handler and the Comedy Central duo of Stewart and Colbert, and a device ? a large number of people take that time to watch programs they had taped earlier on their DVRs.
NBC is worried that Kimmel will establish himself as a go-to late night performer for a younger generation if the network doesn't move swiftly to install Fallon. ABC moved Kimmel's time slot to directly compete with Leno earlier this year.
But the move also has the potential to backfire with Leno's fans, who did not embrace O'Brien when Leno was temporarily moved to prime time a few years ago.
"The guys at NBC are not totally stupid and are not going to shoot themselves in the foot," said Gary Carr, senior vice president and executive director of national broadcast for the ad buying firm TargetCast. "I think it's a good move for them long-term. But it may have short-term ramifications."
NBC has long prided itself on smooth transitions, but that reputation took a hit with the short-lived and ill-fated move of O'Brien to "Tonight" and Leno to prime time. In morning television, the "Today" show has taken a ratings nose dive in large measure because of anger at how Ann Curry was treated when she was ousted last year as Matt Lauer's co-host.
The Leno-Fallon changeover didn't begin smoothly. Leno had been cracking jokes about NBC's prime-time futility, angering NBC entertainment chief Robert Greenblatt, who sent a note to Leno telling him to cool it. That only made Leno go after NBC management much harder.
The first public effort toward making the transition smooth came Monday night, when Leno and Fallon appeared in a comic video making fun of the late-night rumors. It aired in between each man's show.
John Dawson, general manager for five NBC affiliates that have extensive reach throughout Kansas, said it will be difficult to give up a program that wins its time period by 33 percent.
"Jay has always been a great friend to the affiliates," he said. "For that alone it will be hard to give up."
But he said he believes in Fallon and in NBC's corporate owner, Comcast Corp., the nation's largest cable company.
"Comcast certainly knows how to launch entertainment programming," Dawson said.
___
Associated Press television writers Lynn Elber in Los Angeles and Frazier Moore in New York, and AP writer Nicole Evatt in Los Angeles contributed to this report.
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The 10 creepiest teachers who allegedly banged or tried to molest students last month [SLIDESHOW]
The national epidemic of teacher-student sex stories marches on unabated. The state of Texas, with four of these 10 incidents, is seemingly leading the way.
The Daily Caller had been whipped together one of these slideshows each week. That remains entirely possible, but it started to border on tedious. Here, then, is the greatest hits of teacher-student sex stories that appeared on respectable national and local news websites during the month of March.
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Join the conversation on The Daily Caller
Read more stories from The Daily Caller
The 10 creepiest teachers who allegedly banged or tried to molest students last month [SLIDESHOW]
Limbaugh: Obama Easter Sunday church presence inspired pastor's racism [AUDIO]
Obama has a rough day on the court [VIDEO]
Now it's conservatives who must wait for the world to change
Hear Gary Busey's insane thoughts on Easter [VIDEO]
Source: http://news.yahoo.com/10-creepiest-teachers-allegedly-banged-tried-molest-students-042038974.html
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